An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Getting through a COVID-19 winter: Physical coldness increases the perceived risk of coronavirus diseaseResearch article Published on 2023-01-012022-10-05 Journal: Personality and Individual Differences [Category] 진단, [키워드] Affect assigned Attribute substitution model Chinese conditions Contagion control condition coronavirus coronavirus disease Coverage COVID-19 diagnostic disease Disease risk perception disease transmission Embodiment environmental factor evaluate Evidence Factor feature genetic susceptibility Health increase information less likelihood Local media New coronavirus participant Perceived risk Physical coldness Probability Randomly recruit reported Research risk temperature visceral [DOI] 10.1016/j.paid.2022.111799 [Article Type] Research article
The influencing factors of discrimination against recovered Coronavirus disease 2019 (COVID-19) patients in China: a national studyArticle Published on 2022-12-312022-10-04 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 임상, [키워드] age analyzed association Chinese corona virus disease 2019 Coronavirus disease 2019 COVID-19 COVID-19 knowledge COVID-19 vaccination determinant discrimination disease disease knowledge Factor female GDP geographical location Infection interactions knowledge logistic regression model men and women National Older over participant Participants Patient physician Physicians Quantitative quarantine Randomly recommendation recovered COVID-19 patient Recovered COVID-19 patients recovered COVID-19 patients. reduce Region scored selected Transmission Treatment Virus Disease was used women [DOI] 10.1080/21645515.2021.1913966 PMC 바로가기 [Article Type] Article
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Assessing the transition of COVID-19 burden towards the young population while vaccines are rolled out in China중국에서 백신이 출시되는 동안 젊은 인구에 대한 COVID-19 부담의 전환 평가Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] absence Admissions age Assessing cause children China Chinese coronavirus disease Coronavirus disease 2019 Coverage COVID-19 deaths decrease Delta delta variant disease Effectiveness effort eligible Epidemics fatality groups highlight Hospitalization hospitalizations incidence include individual Infants Infection intensive care lineages novel Novel coronavirus novel coronavirus disease Novel coronavirus disease 2019 Older age over SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 transmission symptomatic infection symptomatic infections target population transition transition of disease burden Transmission triggered vaccinated against COVID-19 vaccination vaccination. Vaccine widespread [DOI] 10.1080/22221751.2022.2063073 PMC 바로가기 [Article Type] Article
Mapping post-traumatic stress disorder symptoms and quality of life among residents of Wuhan, China after the COVID-19 outbreak: A network perspectiveResearch article Published on 2022-12-012022-10-05 Journal: Journal of affective disorders [Category] 진단, [키워드] approach Attention changes in checklist Chinese Civilian Community conducted connection covariates COVID-19 COVID-19 outbreak cross-sectional cross-sectional survey emotional examined Follow-up General population initial lack life limitation mapping mental health network analysis objective outbreak pandemic participant Perspective Post-traumatic stress disorder Post-traumatic stress disorder symptoms Quality Quality of life Result self-report measure Study design Symptom Version were measured World Health Organization Wuhan Wuhan residents Wuhan, China [DOI] 10.1016/j.jad.2022.08.074 [Article Type] Research article
An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variantsSARS-CoV-2 오미크론 변이체에 감염된 중국 참가자의 VV116에 대한 공개, 전향적 코호트 연구Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] adjusted administration adverse event adverse events anti-SARS-CoV-2 antiviral drug baseline characteristics Chinese Cohort cohort study collected conducted control group COVID-19 Cox regression analysis effective Effectiveness Efficacy enrolled evaluate first positive Follow-up Hospitalized infected with SARS-CoV-2 Infection Intervention median time no significant difference omicron Omicron variant participant Patient preclinical studies predominant Prevalence prospective cohort study receive regression analysis reported resolved robust Safe Serious Adverse Event Serious Adverse Events standard treatment Symptom symptomatic treatment group variant variant of SARS-CoV-2 Viral load Viral load. viral shedding VV116 with COVID-19 [DOI] 10.1080/22221751.2022.2078230 PMC 바로가기 [Article Type] Article
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trialArticle Published on 2022-12-012022-10-06 Journal: The Lancet Regional Health - Western Pacific [Category] 진단, [키워드] acute respiratory syndrome Administered Adults adverse event AEs age analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccination. vaccine administration were blinded [DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article
Robust neutralizing antibody response to SARS-CoV-2 mRNA vaccination in adolescents and young adults with childhood-onset rheumatic diseasesArticle Published on 2022-11-022022-11-15 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, 치료기술, [키워드] adverse event childhood-onset rheumatic disease Chinese Cohort COVID-19 COVID-19 infection cPass™ cut-off defined disease Disease activity dose Efficacy evaluate female first vaccination humoral immunogenicity immunogenicity increased the risk inhibition median medication Most patient mounted mRNA vaccination mRNA vaccine neutralization Neutralizing antibodies Neutralizing antibody response neutralizing response not affect Paediatric age paediatric rheumatology Patient positive predictor proportion remained response rheumatic disease SARS-CoV-2 SARS-CoV-2 vaccine second vaccination Serious Adverse Event serious complication Seven Subgroup analysis symptomatic the SARS-CoV-2 the vaccine two-dose regimen vaccination Vaccine vaccine efficacy vaccine safety. were assessed [DOI] 10.1093/rheumatology/keac105 PMC 바로가기
Attitude toward COVID-19 vaccines and its association with depressive symptoms in 386,924 Chinese primary school students during COVID-19 epidemic normalizationResearch article Published on 2022-11-012022-10-05 Journal: Journal of psychosomatic research [Category] 변종, [키워드] 95% confidence interval addition adjusted odds ratio Analysis association Attitude children China Chinese Cluster COVID-19 COVID-19 epidemic COVID-19 infection COVID-19 vaccine COVID-19 vaccines cross-sectional depressive symptom Depressive symptoms evaluate evaluated Factor Government information inventory involved lower risk multiple logistic regression Participants positive attitude Prevalence promote PROTECT reliability Result Safe School the vaccine vaccination Vaccine was used were used [DOI] 10.1016/j.jpsychores.2022.111021 [Article Type] Research article